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Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity.
J Biol Chem. 2023 Jul;299(7):104890. doi: 10.1016/j.jbc.2023.104890. Epub 2023 Jun 5.
J Biol Chem. 2023.
PMID: 37286039
Free PMC article.
Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function.
Sekiya M, Ma Y, Kainoh K, Saito K, Yamazaki D, Tsuyuzaki T, Chen W, Adi Putri PIP, Ohno H, Miyamoto T, Takeuchi Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Motomura K, Matsuzaka T, Murata K, Mizuno S, Takahashi S, Shimano H.
Sekiya M, et al. Among authors: adi putri pip.
Cell Rep. 2023 Aug 29;42(8):112914. doi: 10.1016/j.celrep.2023.112914. Epub 2023 Aug 8.
Cell Rep. 2023.
PMID: 37557182
Free article.
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