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Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity.
Saito K, Sekiya M, Kainoh K, Yoshino R, Hayashi A, Han SI, Araki M, Ohno H, Takeuchi Y, Tsuyuzaki T, Yamazaki D, Wanpei C, Hada L, Watanabe S, Paramita Adi Putri PI, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Miyamoto T, Matsuzaka T, Shimano H. Saito K, et al. Among authors: paramita adi putri pi. J Biol Chem. 2023 Jul;299(7):104890. doi: 10.1016/j.jbc.2023.104890. Epub 2023 Jun 5. J Biol Chem. 2023. PMID: 37286039 Free PMC article.
Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function.
Sekiya M, Ma Y, Kainoh K, Saito K, Yamazaki D, Tsuyuzaki T, Chen W, Adi Putri PIP, Ohno H, Miyamoto T, Takeuchi Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Motomura K, Matsuzaka T, Murata K, Mizuno S, Takahashi S, Shimano H. Sekiya M, et al. Among authors: adi putri pip. Cell Rep. 2023 Aug 29;42(8):112914. doi: 10.1016/j.celrep.2023.112914. Epub 2023 Aug 8. Cell Rep. 2023. PMID: 37557182 Free article.